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Evid Based Nurs 10:10 doi:10.1136/ebn.10.1.10
  • Treatment

Immediate or delayed prescribing of antibiotics reduced duration of symptoms in acute infective conjunctivitis


 
 Q What is the effectiveness of immediate, delayed, or no prescribing of antibiotics for acute infective conjunctivitis?

METHODS

GraphicDesign:

factorial 3×2×2 randomised controlled trial.

GraphicAllocation:

{concealed}.*

GraphicBlinding:

unblinded.

GraphicFollow up period:

2 weeks.

GraphicSetting:

30 general practices in the UK.

GraphicPatients:

307 adults and children ⩾1 year of age (mean age 28 y, 57% women and girls) with acute infective conjunctivitis. Exclusion criteria were systemic unwellness requiring oral antibiotics, recent antibiotic use, chronic infective eye disease, recent eye surgery, or allergy to chloramphenicol.

GraphicIntervention:

immediate prescription of antibiotics (chloramphenicol eye drops every 2 h for 2 d, then 4 times/d) (n = 104), delayed prescription of antibiotics (collection of prescription from the general practitioner after 3 d at patients’ or parents’ discretion) (n = 109), or no antibiotics (could receive treatment in …

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