Evid Based Nurs 1:118 doi:10.1136/ebn.1.4.118
  • Treatment

A non-prescription analgesic alleviated migraine headache pain and symptoms

 Question In patients with a history of migraine headache, can a non-prescription combination product (Excedrin Extra-Strength that contains acetaminophen [paracetamol], aspirin, and caffeine) reduce migraine headache pain and symptoms?


3 randomised, double blind, placebo controlled trials with data combined for presentation.


20 clinical centres in the US.


1357 patients (mean age 36.7 y, 79% women) with a history of confirmed migraine headaches (International Headache Society criteria). Inclusion criteria were age ≥18 years, good health, migraine headache frequency from 1 headache every 2 months to 6 each month, moderate headache pain without treatment, and vomiting <20% of the episodes. 92% of patients used their assigned medication.


677 patients were allocated to active medication (2 tablets of unbranded Excedrin Extra-Strength tablets, Bristol-Myers Squibb, that contained acetaminophen, 250 mg; …

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