Review: morphine, eutectic mixture of local anaesthetics, ketorolac, and sucrose reduce postoperative and procedural pain in children
Question Which pharmacological interventions are effective for managing acute postoperative or procedural pain in children?
Studies from 1987–96 were identified by searching Medline, CINAHL, CancerLit, and AIDSLINE using combinations of search terms including pain, analgesia, anesthetics, opioids, and age related terms (eg, neonate and toddler). Bibliographies of relevant articles were also reviewed.
Studies were included if they tested a pharmacological intervention using a prospective design in a sample of ≥30 people <20 years of age who were randomly allocated to ≥2 groups. Studies had to provide adequate methodological and statistical details for review.
Data were extracted on type of pain, age of children, study design, type of intervention, outcomes and measurement approaches, and results.
41 studies of acute pain met the inclusion criteria. 22 studies focused on postoperative pain and 19 focused on pain associated with procedures (venipuncture, circumcision, suturing, heelsticks, immunisations, port wine stain removal, and intravenous [IV] port access). Study sample size ranged …