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Calcium and vitamin D reduced non-vertebral fractures and bone loss in the elderly

https://doi.org/10.1136/ebn.1.2.48

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    Dawson-Hughes B, Harris SS, Krall EA , et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997 Sep 4; 337 : 670 –6. OpenUrlCrossRefPubMedWeb of Science

    Objective

    To assess the effectiveness of combined oral calcium and vitamin D supplementation in reducing non-vertebral fractures and bone loss in elderly people living in the community.

    Design

    3 year randomised, double blind, placebo controlled trial.

    Setting

    Community based study in the USA.

    Participants

    445 healthy people living in the community who were ≥65 years of age (55% women) were enrolled and 389 (mean age 71 y) were included in the intention to treat analysis. Exclusion criteria were current cancer or hyperparathyroidism; a kidney stone in the past 5 years; renal disease; bilateral hip surgery; bisphosphonate, calcitonin, oestrogen, tamoxifen, or …

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    Footnotes

    • Sources of funding: National Institutes of Health and the Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University.

    • For article reprint: Dr B Dawson-Hughes, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Sreet, Boston, MA 02111, USA.

    • Adapted from an abstract published in ACP Journal Club 1998 Mar-Apr;128:44.