© 2000 Evidence-Based Nursing
Supplemental oxygen did not reduce progression of pre-threshold retinopathy of prematurity in infants
The STOP-ROP Multicenter Study Group.Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes.Pediatrics 2000 Feb;105:295–310
QUESTION: In premature infants, is supplemental oxygen at pulse oximetry saturations of 96% to 99% more effective than conventional oxygen at pulse oximetry saturations of 89% to 94% in reducing the progression from moderate (pre-threshold) to threshold retinopathy of prematurity (ROP)?
Randomised (allocation concealed), blinded (outcome assessor), controlled trial with 3 months of follow up.
71 hospitals affiliated with 30 centres in the US.
649 infants (mean gestational age 25 wks, 57% boys, 55% white) who were born prematurely, had pre-threshold ROP in 
1 eye, and had a median pulse oximetry 
94% oxygen saturation in room air. Infants were excluded if they had lethal anomalies or congenital anomalies of the eye. Follow up was 92%.
After stratification by study centre and 2 levels of baseline ROP severity, infants were randomised to receive supplemental oxygen therapy with pulse oximetry targeted at 96% to 99% oxygen saturation (supplemental group, n=324) or conventional oxygen therapy with pulse oximetry targeted at 89% to 94% oxygen saturation (conventional group, n=325) for 2 weeks.
The main outcome measure was the rate of progression to threshold ROP in 1 eye. Secondary outcome measures were other ophthalmic and adverse
Assistant Professor, College of Nursing Arizona State University Tempe, Arizona, USA
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