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Evidence-Based Nursing 2000;3:113; doi:10.1136/ebn.3.4.113
Copyright © 2000 by BMJ Publishing Group Ltd & RCN Publishing Company Ltd.
Evidence-Based Nursing 2000; 3:113
© 2000 Evidence-Based Nursing

Review: daily maintenance inhaled corticosteroidsare not effective for children with episodic viral wheeze

McKean M, Ducharme F. Inhaled steroids for episodic viral wheeze of childhood. (Cochrane Review, latest version 26 Oct 1999). In: Cochrane Library. Oxford: Update Software.

QUESTION: Are inhaled corticosteroids, given episodically or daily, effective for treatment of children with viral episodic wheeze?

Data sources

Published and unpublished randomised controlled trials were identified in April 1999 by searching the Cochrane Airways Group database (which includes studies identified from searches of Medline, EMBASE/Excerpta Medica, CINAHL, and hand searches of 16 core respiratory journals and the proceedings of 3 respiratory societies) using combinations of the terms asthma, wheez* (truncated), budesonide, pulmicort, beclomethasone, becotide, fluticasone, flixotide, triamcinolone, steroid, corticosteroid, glucocorticoid, inhaled, aerosolised, nebulised, child, infan*, pediatric, paediatric, and adolescen*; bibliographies of retrieved trials; and contacting authors.

Study selection

Studies were included if they involved children aged 0–17 years with viral episodic wheeze (defined as >=2 episodes of wheezing associated with clinical viral infection with minimal or no symptoms between exacerbations). Studies of children with classical chronic asthma (ie, wheezing episodes caused by stimuli other than viruses) or chronic lung disease were excluded.

Data extraction

Data were extracted on study design and methods, characteristics of participants, interventions, and outcomes (main outcome was episodes . . . [Full text of this article]

Gene Elizabeth Harkless, RN, DNSc, ARNP

Associate Professor/Family Nurse Practitioner Department of Nursing, University of New Hampshire Durham, New Hampshire, USA


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