© 2000 Evidence-Based Nursing
Review: allylamines, azoles, undecenoic acid, and tolnaftate are effective for fungal skin infections of the foot
Crawford F, Hart R, Bell-Syer S, et al. Topical treatments for fungal infections of the skin and nails of the foot. (Cochrane Review, latest version 10 May 1999). In: Cochrane Library. Oxford: Update Software.
QUESTION: Are topical treatments effective for fungal infections of the skin and nails of the foot?
Studies were identified using Medline (1966 to December 1997), EMBASE/Excerpta Medica (1980 to December 1997), CINAHL (inception to December 1997), Cochrane Controlled Trials Register, Science and Social Science Citation Indexes, CAB–Health, Healthstar, DARE, NHS Economic Evaluation, and EconLit and by scanning bibliographies of relevant and unpublished studies, handsearching journals, and contacting drug companies and experts.
Randomised controlled trials were selected if they evaluated topical treatments for mycologically diagnosed fungal infections of the skin and nails of the foot.
Study methodology and quality, participant characteristics, intervention regimens and costs, mycological cure or recurrence, quality of life, and adverse events.
126 trials were identified and 72 (70 of treatment of skin infections of the foot and 2 of treatment of nail infections of the foot) met the inclusion criteria. Allylamines, azoles, undecenoic acid, and tolnaftate had lower failure to cure rates than placebo for fungal skin infections of the foot (table
).
Assistant Professor, Nurse Practitioner Options College of Nursing, University of Arizona Tucson, Arizona, USA
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