© 2000 Evidence-Based Nursing
Review: penicillin V is better than placebo and equal to non-penicillins for acute maxillary sinusitis
Williams Jr JW, Aguilar C, Makela M, et al. Antimicrobial therapy for acute maxillary sinusitis. (Cochrane Review, latest version 26 May 1999.) In: Cochrane Library. Oxford: Update Software.
QUESTION: In adults with acute maxillary sinusitis, which antibiotics lead to higher clinical cure rates?
Studies were identified by searching Medline and EMBASE/Excerpta Medica (to October 1998) with the heading sinusitis and terms for randomised controlled trials, scanning bibliographies of relevant articles, and contacting pharmaceutical companies and experts in the field.
Studies were selected if they were randomised controlled trials (RCTs) that compared an antibiotic with placebo or another class of antibiotic in 
30 patients who were 18 years of age and had a history consistent with acute maxillary sinusitis confirmed by radiography or aspiration.
2 or more reviewers independently extracted data on study characteristics; interventions; study duration; length of follow up; cointerventions; compliance; and clinical, bacteriological, radiographic, and adverse event outcomes.
32 RCTs (7330 patients) with 34 comparisons met the inclusion criteria. Treatment duration ranged from 3–15 days. Penicillin V led to an increase in clinical cure rate (table
). No difference in clinical cure rate was seen for amoxicillin compared with control in
Family Nurse Practitioner and Nursing Faculty The Geisinger Health System and Lycoming College Williamsport, Pennsylvania, USA
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