TREATMENT
Review: low molecular weight heparin reduces risk of venous thromboembolism in adults with leg immobilisation
| The first 150 words of the full text of this article appear below. |
In adults with leg immobilisation, does low molecular weight heparin (LMWH) prevent venous thromboembolism (VTE)?
Included studies compared LMWH with placebo or no thromboprophylaxis in adults with a leg injury requiring immobilisation in a plaster cast or brace in an ambulatory setting. Outcomes were symptomatic or asymptomatic VTE (deep venous thrombosis [DVT] or pulmonary embolism) and bleeding events.
Cochrane Peripheral Vascular Diseases Group Specialised Register, PubMed, and EMBASE/Excerpta Medica (May 2008); Cochrane Central Register of Controlled Trials (Issue 2, 2008); and reference lists were searched for randomised controlled trials (RCTs) and controlled clinical trials. Pharmaceutical companies were consulted. 6 RCTs (n = 1490, mean age 34–49 y, 46–79% men) met the selection criteria. DVT was diagnosed by venography or by compression ultrasonography and/or duplex scanning confirmed by phlebography or venography. 4 trials reported adequate concealment of allocation, 3 placebo-controlled trials were double-blinded, and the outcome assessor was blinded in 1
Berkshire Medical Centre, Pittsfield, Massachusetts, USA
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
