TREATMENT
Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezing
| The first 150 words of the full text of this article appear below. |
Does a short course of oral prednisolone improve outcomes in preschool children with an attack of wheezing associated with upper respiratory viral infection?
Design: randomised placebo-controlled trial. ISRCTN58363576 [controlled-trials.com] .
Allocation: concealed.
Blinding: blinded (patients, parents, healthcare providers, and outcome assessors).
Follow-up period: 1 month.
Setting: 3 hospitals in the UK.
Patients: 700 children 10–60 months of age (mean age 26 mo, 64% boys) who presented to hospital with an attack of wheezing associated with a clinically diagnosed upper respiratory viral infection. Exclusion criteria included shock, bacterial sepsis, heart or lung disease, immunodeficiency or immunosuppressive therapy, and varicella infection or recent exposure.
Intervention:
oral prednisolone (10 mg/d if 
24 mo of age or 20 mg/d if >24 mo) once daily for 5 days (n = 343) or placebo (n = 344).* All patients received inhaled salbutamol as required and other treatment at the discretion of the attending physician.
Outcomes:
time to
University of Auckland School of Nursing, Auckland, Aotearoa, New Zealand
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