TREATMENT
Ginkgo biloba did not prevent dementia or Alzheimer disease in elderly people
| The first 150 words of the full text of this article appear below. |
S T DeKosky
Dr S T DeKosky, University of Virginia School of Medicine, Charlottesville, VA, USA; dekosky@virginia.edu
Does Ginkgo biloba reduce incident dementia and Alzheimer disease in elderly people with normal cognition or mild cognitive impairment?
Design: randomised placebo controlled trial (Ginkgo Evaluation of Memory [GEM] study). ClinicalTrials.gov NCT00010803 [ClinicalTrials.gov] .
Allocation: unclear allocation concealment.*
Blinding: blinded (patients, clinicians, and outcome assessors).*
Follow-up period: median 6.1 years.
Setting: 5 academic medical centres in the USA.
Participants:
3069 participants >75 years of age (mean age 79 y, 54% men) who had normal cognition or mild cognitive impairment (impaired at 
10th percentile of Cardiovascular Health Study normative data on 2 of 10 neuropsychological tests and Clinical Dementia Rating global score of 0.5). Exclusion criteria included dementia; bleeding disorders; Parkinson disease; receipt of warfarin, cholinesterase inhibitors, antidepressants, or antipsychotics; abnormal thyroid tests, serum creatinine concentration >2 mg/dl (>176.8 µmol/l), or liver function test result
HeSAS, University of Glamorgan, Pontypridd, Wales, UK
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