TREATMENT
Review: tight glucose control increases risk of hypoglycaemia but not short-term mortality in critically ill adults
| The first 150 words of the full text of this article appear below. |
R Wiener
Dr R Wiener, Department of Veterans Affairs Medical Center, White River Junction, VT, USA; renda.s.wiener@dartmouth.edu
What are the benefits and risks of tight glucose control in critically ill adults?
Included studies compared tight glucose control (glucose goal <150 mg/dl [8.3 mmol/l] using an insulin infusion) with usual care in patients in adult intensive care units (ICUs) and had one of the outcomes of interest as a primary or secondary end point. Studies of primarily intraoperative interventions or that could not provide adequate outcome or methodological data were excluded. Outcomes of interest were hospital or 30-day mortality, septicaemia (sepsis, septicaemia, bacteraemia, or positive blood cultures), need for dialysis in patients without a pre-existing need, and hypoglycaemia (
1 blood glucose measurement 
40 mg/dl [2.2 mmol/l]).
Medline (1950 to Jun 2008), Cochrane Library (Issue 1, 2008), trial registries (Aug 2007), conference abstracts of American Thoracic Society (2001–8) and Society of
National Centre for Clinical Outcomes Research, Australian Catholic University, North Sydney, New South Wales, Australia
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