TREATMENT
Vitamin E or vitamin C supplements did not differ from placebo for major cardiovascular events and mortality
| The first 150 words of the full text of this article appear below. |
H D Sesso
Dr H D Sesso, Brigham and Women’s Hospital, Boston, MA, USA; hsesso@hsph.harvard.edu
In men at lower risk of cardiovascular disease (CVD), do vitamin E and vitamin C supplements reduce major CVD events?
Design: randomised placebo controlled trial (Physicians’ Health Study II). ClinicalTrials.gov NCT00270647 [ClinicalTrials.gov] .
Allocation: unclear allocation concealment.
Blinding: blinded (patients, clinicians, and outcome assessors)
Follow-up period:
10 years (mean 8 y).
Setting: USA.
Patients:
14 641 male physicians 
50 years of age (mean age 64 y). Men with a history of myocardial infarction (MI), stroke, or cancer were included. Exclusion criteria were history of cirrhosis, active liver disease, anticoagulant use, or serious illness. 5.1% of men had prevalent CVD.
Intervention:
after stratification for age, previous cancer or CVD diagnosis, and previous β-carotene assignment, men were allocated to vitamin E, 400 IU every other day (n = 3659); vitamin C, 500 mg/day (n = 3673); vitamin E
University of Victoria School of Nursing Victoria, British Columbia, Canada
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