TREATMENT
Review: weight-reducing agents improve glycaemic control and reduce progression to diabetes
| The first 150 words of the full text of this article appear below. |
S Czernichow
Dr S Czernichow, Unite de Recherche en Nutrition Humaine, Bobigny, France; s.czernichow@uren.smbh.univ-paris13.fr
How do weight-reducing agents affect glycaemic parameters and risk of type 2 diabetes in predisposed individuals?
Included studies were randomised, double-blind, placebo controlled trials (RCTs) that evaluated the effects of weight-reducing agents (eg, orlistat, sibutramine, and rimonabant) on fasting glucose or glycated haemoglobin (HbA1c) concentrations and had a duration of 
1 year. Studies of mixed populations were excluded. Outcomes included weight loss, fasting glucose and HbA1c concentrations, and diabetes.
Medline was searched from November 1987 to May 2007. 23 RCTs met the selection criteria: 8 (n = 2848, mean age 55 y) assessed people with diabetes, and 15 (n = 11 821, mean age 44 y) assessed people without diabetes. All RCTs evaluated drug therapy (orlistat, 120 mg/d; sibutramine, 10–20 mg/d; or rimonabant, 20 mg/d) plus reduced-calorie diets. Meta-analysis was not done because of heterogeneity
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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