TREATMENT
Paracetamol plus ibuprofen increased time without fever compared with paracetamol but did not differ from ibuprofen in children
| The first 150 words of the full text of this article appear below. |
A D Hay
Dr A D Hay, University of Bristol, Bristol, UK; alastair.hay@bristol.ac.uk
How does paracetamol (PCM) plus ibuprofen (IBF) compare with either drug alone for treating fever in children?
Design: randomised controlled trial (Paracetamol plus Ibuprofen for the Treatment of fever in CHildren [PITCH]). Current Controlled Trials ISRCTN26362730 [controlled-trials.com] .
Allocation: concealed.
Blinding: blinded (nurses, {patients, data collectors, outcome assessors, data analysts, and safety committee}*).
Follow-up period: 48 hours.
Setting: 35 primary care sites in Bristol, UK.
Patients: 156 children (mean age 2 y, age range 6 mo to 6 y, 56% boys) who had axillary temperatures of 37.8°C to 41°C. Exclusion criteria included need for hospital admission; dehydration; chronic disease; or contraindication to trial drugs.
Interventions:
PCM, 15 mg/kg (every 4–6 h, maximum 4 doses/d), plus IBF, 10 mg/kg (every 6–8 h, maximum 3 doses/d) (combination therapy) (n = 52); PCM alone (n = 52); or IBF alone (n
Columbia University School of Nursing, New York, New York, USA
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