TREATMENT
Benefits of early intensive glucose control in preventing diabetes-related complications were sustained for up to 10 years
| The first 150 words of the full text of this article appear below. |
R R Holman
Dr R R Holman, Churchill Hospital, Oxford, UK; rury.holman@dtu.ox.ac.uk
In patients with type 2 diabetes, do the benefits of early intensive glucose control in preventing diabetes-related complications continue after the intervention is stopped?
Design: randomised controlled trial (UK Prospective Diabetes Study [UKPDS]).
Allocation: {concealed}.*
Blinding: blinded (outcome adjudication committee).
Follow-up period: median 9 years after the end of the trial, 17 years total.
Setting: 23 centres in the UK.
Patients: 4209 patients 25–65 years of age {mean age 53 y, 60% men}* who had newly diagnosed type 2 diabetes and fasting plasma glucose concentrations >6.0 mmol/l (108 mg/dl) and <15.0 mmol/l (270 mg/dl) after 3 months of dietary therapy. Exclusion criteria included ketonuria, elevated serum creatinine, recent myocardial infarction, angina, heart failure, and >1 major vascular event.
Intervention:
intensive glucose control with a sulfonylurea or insulin (n = 2729) or conventional therapy with diet (n = 1138).
School of Nursing, McMaster University, Hamilton, Ontario, Canada
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