TREATMENT
Intensive glucose control increased mortality and did not prevent cardiovascular events in type 2 diabetes
| The first 150 words of the full text of this article appear below. |
R P Byington
Dr R P Byington, Wake Forest University School of Medicine, Winston-Salem, NC, USA; bbyingto@wfubmc.edu
In patients with type 2 diabetes and cardiovascular disease or risk factors, does intensive glucose control prevent cardiovascular events more than standard glucose control?
randomised controlled trial (Action to Control Cardiovascular Risk in Diabetes [ACCORD]).
concealed.
blinded (outcome adjudication committee and laboratory staff).
median 3.4 years.
7 centres in the USA and Canada.
10 251 patients 40–79 years of age (mean age 62 y, 61% men) who had type 2 diabetes, glycated haemoglobin (HbA1c) concentration 
7.5%, and cardiovascular disease or, if 55 years of age, risk factors for cardiovascular disease. Exclusion criteria included body mass index >45 kg/m2, serum creatinine concentration >1.5 mg/dl (132 mmol/l), and frequent or recent serious hypoglycaemia.
intensive glucose control to achieve a target HbA1c concentration <6.0% (n = 5128) or standard glucose control to achieve a
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