TREATMENT
Review: low-molecular-weight heparin prevented recurrent VTE more than oral anticoagulants in patients with cancer
| The first 150 words of the full text of this article appear below. |
E A Akl
Dr E A Akl, State University of New York at Buffalo, Buffalo, NY, USA; elieakl@buffalo.edu
In patients with cancer and venous thromboembolism (VTE), is long-term treatment with low-molecular-weight heparin (LMWH) effective and safe compared with oral anticoagulants?
Studies selected compared LMWH with oral anticoagulants (vitamin K antagonists or ximelagatran) for long-term treatment in patients with cancer and objectively diagnosed VTE. Outcomes were mortality, symptomatic recurrent VTE, major bleeding, and thrombocytopenia.
Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, and ISI the Web of Science (to Jan 2007); conference proceedings; reference lists; and the "related articles" feature of PubMed were searched for randomised controlled trials (RCTs). Drug companies were consulted. 6 RCTs (n = 1661) met the selection criteria. 3 trials reported adequate allocation concealment, and 4 reported blinding of outcome assessors. Follow-up ranged from 3 to 12 months.
Compared with vitamin K antagonists, LMWH reduced recurrent
University of British Columbia, Vancouver, British Columbia, Canada
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