TREATMENT
Review: evidence on the effectiveness of interventions to improve patient adherence to prescribed medications is limited
| The first 150 words of the full text of this article appear below. |
R B Haynes
Professor R B Haynes, McMaster University, Hamilton, Ontario, Canada; bhaynes@mcmaster.ca
Are interventions to improve patient adherence to self- administered prescribed medications effective?
Studies selected evaluated interventions to improve adherence to medications prescribed for medical disorders (including mental but not addiction disorders), had 
80% follow-up in each study group, reported both medication adherence and treatment outcomes, and had 6 month follow-up in trials of long-term treatments that had positive initial results.
Medline, CINAHL, EMBASE/Excerpta Medica, Cochrane Library, International Pharmaceutical Abstracts, PsycINFO, and Sociological Abstracts (all to Jan 2007); and reference lists were searched for randomised controlled trials (RCTs). Authors of relevant trials and reviews were contacted. 78 RCTs ({93}* unconfounded interventions, 10 with short-term treatment and {83}* with long-term treatment; n = 32–1113) met the selection criteria; 20 reported concealment of allocation. Conditions studied included asthma or chronic obstructive pulmonary disease (11 RCTs), HIV (12 RCTs), hypertension
Ohio State University College of Nursing, Columbus, Ohio, USA
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Hypertension
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Psychotic disorders (incl schizophrenia)
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Drugs misuse (including addiction)
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Diabetes
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