Treatment
The Atkins diet led to more weight loss than the Zone diet in overweight and obese premenopausal women at 12 months
Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA 2007;297:969–77.
Q What is the relative effectiveness of Atkins, Zone, "Lifestyle, Exercise, Attitudes, Relationships, and Nutrition (LEARN)," and Ornish diets for weight loss in overweight or obese premenopausal women?
Key Words: diet fads • diet (reducing) • obesity • weight loss
| The first 150 words of the full text of this article appear below. |
Design:
randomised controlled trial (Atkins, Traditional, Ornish, Zone [A TO Z] Weight Loss Study).
Allocation:
unclear allocation concealment.
Blinding:
blinded {data collectors, data analysts, and safety and monitoring committee}.*
Follow-up period:
12 months.
Setting:
United States.
Patients:
311 premenopausal women 25–50 years of age (mean age 41 y, 71% white) who were overweight or obese (body mass index [BMI] 27–40 kg/m2), had stable weight in the past 2 months, and stable medications for 
3 months. Exclusion criteria included diabetes; hyperthyroidism; hypertension; heart, renal, or liver disease; cancer; use of drugs affecting weight or energy expenditure; 3 drinks of alcohol/day; pregnancy; lactation; and amenorrhoea in the past year.
Intervention:
Atkins (very low carbohydrates [carbs]) (n = 77), Zone (low carbs) (n = 79), LEARN (low fat, high carbs) (n = 79), or Ornish (very high carbs) (n = 76) for 8 weeks. All women attended classes (1 h/wk for 8
University of New Brunswick, Fredericton, New Brunswick, Canada
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