Treatment
Review: timing or administration route of nutritional support does not affect death or disability in head injury
Perel P, Yanagawa T, Bunn F, et al. Nutritional support for head-injured patients. Cochrane Database Syst Rev 2006;(4):CD001530.[Medline]
Q In patients with head injury, does timing or route of nutritional support affect morbidity and mortality?
Key Words: craniocerebral trauma • nutritional support
| The first 150 words of the full text of this article appear below. |
Data sources:
Cochrane Injuries Group specialised register, Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, Web of Science, CAB Abstracts, CINAHL, National Research Register, ZETOC, and reference lists of identified studies and reviews.
Study selection and assessment:
randomised controlled trials (RCTs) evaluating timing (early v delayed) or administration routes (parenteral v enteral or gastric v jejunal enteral) of nutritional support in patients with acute traumatic brain injury of any severity. 11 RCTs (n = 534) met the inclusion criteria. 7 RCTs evaluated timing, and 7 RCTs evaluated administration route. Quality assessment of individual trials was based on adequacy of allocation concealment, which was unclear in 7 trials and inadequate in 4 trials.
Outcomes:
all cause mortality, disability (Glasgow Coma Scale dichotomised such that death, persistent vegetative state, or severe disability = poor outcome and moderate disability or good recovery = good outcome), length of hospital stay, and infection.
Of
Otago District Health Board,
Dunedin, New Zealand
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