Treatment
Review: lifestyle or pharmacological interventions prevent or delay type 2 diabetes in people with impaired glucose tolerance
Gillies CL, Abrams KR, Lambert PC, et al. Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis. BMJ 2007;334>:299.
Q In people with impaired glucose tolerance, do lifestyle or pharmacological interventions prevent or delay type 2 diabetes?
Key Words: diabetes mellitus (type 2) • glucose intolerance • hypoglycaemic agents • life style
| The first 150 words of the full text of this article appear below. |
Data sources:
Medline (1966 to July 2006), EMBASE/Excerpta Medica (1980 to July 2006), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews (Issue 2, 2006), references of relevant articles, and experts.
Study selection and assessment:
randomised controlled trials (RCTs) in any language that evaluated an intervention to delay or prevent type 2 diabetes in people with impaired glucose tolerance and assessed development of diabetes as an outcome. 21 RCTs met the selection criteria, and 17 RCTs (n = 8084, mean age range 39–57 y, mean body mass index range 24–36 kg/m2, average follow up range 0.4–4.6 y) were included in the meta-analysis. Among the 17 RCTs, 8 had quality scores 
3 out of 5 on the Jadad scale, and 2 had allocation concealment.
Outcomes:
development of type 2 diabetes and adverse events.
Meta-analysis using a random effects model showed that both lifestyle interventions (diet, exercise, or both)
University of Texas Health Science Center,
at Houston School of Nursing,
Houston, Texas, USA
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