Treatment
Review: antihistamines, decongestants, or both do not provide benefit in children with otitis media with effusion
Griffin GH, Flynn C, Bailey RE, et al. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2006;(4):CD003423.[Medline]
Q Are antihistamines, decongestants, or both effective in treating children with otitis media with effusion (OME)?
Key Words: histamine H1 antagonists • nasal decongestants • otitis media with effusion
| The first 150 words of the full text of this article appear below. |
Data sources:
Cochrane Ear, Nose, and Throat Disorders Group Trials Register, Cochrane Central Register of Controlled Trials, Medline (1951–2006), EMBASE/Excerpta Medica (1974–2006), grey literature database, references of included trials and relevant reviews, manufacturers of decongestants and antihistamines, and authors in the field.
Study selection and assessment:
randomised controlled trials (RCTs) comparing oral or nasal decongestants or antihistamines with no medication or placebo in children 
18 years of age with OME. Trials in which the data of patients with acute otitis media, anatomical deformity, or other chronic immunocompromised states could not be separated from those of patients meeting criteria were excluded. 16 RCTs (n = 1737) met the selection criteria. The quality of included studies was assessed using the method of Mohar and included randomisation procedure, follow up, blinding, and allocation concealment.
Outcomes:
lack of resolution of effusion at 1 month. Secondary outcomes included lack of resolution at 1–3 months and 
School of Nursing, Dalhousie University,
Halifax, Nova Scotia, Canada
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